I-BLU-9931
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 220 |
| 300mg | Ikhona evenkileni | 500 |
| 1g | Ikhona evenkileni | 1350 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
N-(2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)-3-methylphenyl)acrylamide
Ikhowudi yoncumo:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
Ikhowudi ye-InChi:
InChI=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17 (16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33) (H,29,31,32)
Isitshixo se-InChi:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Igama elingundoqo:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
Kwiiseli ze-MDA-MB-453, i-BLU9931 inqanda ngokufanelekileyo i-phosphorylation ye-FGFR4 indlela yokubonisa. I-BLU9931 inqanda ukwanda kwemigca yeseli ye-HCC evakalisa i-FGFR4 ecacileyo, njenge-Hep 3B, i-HUH-7, kunye nemigca yeseli ye-JHH-7, kunye ne-EC50 ye-<1 μM. I-BLU9931 iphinda inqande ukwanda kwimizila yeseli ye-PDX-derived kunye ne-FGFR4 echanekileyo indlela yokubonisa [1]. I-BLU9931 yenza i-tumor shrinkage kwiimodeli ze-hepatocellular carcinoma ezibonisa i-ligand esebenzayo / i-receptor complex ebandakanya i-FGF19 / FGFR4 / KLB kwaye yongeza kuluhlu olukhulayo lwe-anti-FGFR4 agents [2].
Ithagethi: FGFR4
