I-AZD4547

Igama leMchiza:

N-(5-(3,5-dimethoxyphenethyl)-1H-pyrazol-3-yl)-4-((3S,5R)-3,5-dimethylpiperazin-1-yl)benzamide

Ikhowudi yoncumo:

O=C(NC1=NNC(CCC2=CC(OC)=CC(OC)=C2)=C1)C3=CC=C(N4C[C@H](C)N[C@H](C)C4 )C=C3

Ikhowudi ye-InChi:

InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21( 29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8, 15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+

Isitshixo se-InChi:

VRQMAABPASPXMW-HDICACEKSA-N

Igama elingundoqo:

AZD4547, AZD-4547, AZD 4547, 1035270-39-3

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-AZD 4547 yi-inhibitor ekhethiweyo ye-fibroblast growth factor receptor (FGFR) i-tyrosine kinase enemilinganiselo ye-IC50 ye-0.2, i-2.5, kunye ne-1.8 nM ye-FGFR1, i-2, kunye ne-3, ngokulandelanayo.

Ithagethi: FGFR