OTS964
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 1g | Ikhona evenkileni | 1750 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-enye
Ikhowudi yoncumo:
[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4
Ikhowudi ye-InChi:
InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1
Isitshixo se-InChi:
YHPWOYBWUWSJDW-UQKRIMTDSA-N
Igama elingundoqo:
OTS 964, OTS-964, OTS964, 1338545-07-5
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-OTS964 yi-inhibitor ye-lymphokine-activated killer T cell-originated protein kinase (TOPK; IC50 = 28 nM). Ithintela ngokukodwa i-cytokinesis, ekhokelela kwi-apoptosis, kuluhlu olubanzi lweeseli zomhlaza. I-OTS964 yenza i-apoptosis yeeseli zomhlaza wemiphunga yomntu kwi-xenografts yempuku.
Ithagethi: TOPK
