I-Bardoxolone methyl

Igama leMchiza:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Ikhowudi yoncumo:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Ikhowudi ye-InChi:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

Isitshixo se-InChi:

WPTTVJLTNAWYAO-OROHISIGSA-N

Igama elingundoqo:

I-Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)

Inkcazo:

I-CDDO ye-oleanane triterpenoid yokwenziwa (I-Item No. 81035) yi-activator ye-Nrf2 evimbela ukwanda kwaye ibangele ukuhlukana kunye ne-apoptosis kwiiseli ezahlukeneyo zomhlaza. I-C-28 methyl ester ye-CDDO (i-CDDO methyl ester) ivimbela ukuhlanganiswa kweselula ye-inducible nitric oxide synthase (iNOS) kunye ne-COX-2 ye-inducible kwi-INF-γ-activated mouse macrophages enexabiso le-IC50 le-0.11 nM. Ibangela i-apoptosis, ibangele ukuhlukana, kwaye inqanda impendulo yokuvuvukala kwiiseli ezahlukeneyo ze-tumor ngokusebenzisa ukuvinjelwa kwe-IκBα kinase / NF-κB ukubonakaliswa. I-CDDO ye-methyl ester inomsebenzi onamandla we-antidiabetic, ukunciphisa ukubonakaliswa kwe-proinflammatory cytokine kwi-fat high-feed-feed type 2 iigundane zesifo sikashukela kunye ne-Leprdb / db iigundane kunye nokuqalisa i-AMP-activated protein kinase kunye ne-LKB1 kusebenze kwi-muscle kunye nesibindi.

Ithagethi: NF-kB