GSK2256098

Igama leMchiza:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

Ikhowudi yoncumo:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

Ikhowudi ye-InChi:

InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8- 6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)

Isitshixo se-InChi:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Igama elingundoqo:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Ukunyibilika:Inyibilika kwi-DMSO

Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).

Inkcazo:

I-GSK2256098, eyaziwa ngokuba yi-GTPL7939, i-focal adhesion kinase-1 (FAK) inhibitor ene-antiangiogenic kunye nemisebenzi ye-antineoplastic. I-FAK inhibitor GSK2256098 inhibitha i-FAK, enokuthi ithintele ukusebenza kwe-integrin-mediated yeendlela ezininzi zokuhambisa umqondiso osezantsi, kuquka i-ERK, i-JNK/MAPK kunye ne-PI3K/Akt, ngaloo ndlela inqanda ukufuduka kweeseli zethumba, ukwanda kunye nokusinda, kunye ne-tumor angiogenesis. I-tyrosine kinase FAK idla ngokusetyenziswa ngokubophelela kwii-interins kwi-extracellular matrix (ECM) kodwa inokulawulwa kwaye isebenze ngokusemthethweni kwiintlobo zeeseli zethumba.

Ithagethi: FAK