LX-2761
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
N-(1-((2-(Dimethylamino)ethyl) amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R), 5S,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl)-butanamide
Ikhowudi yoncumo:
O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1
Ikhowudi ye-InChi:
InChI=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21(12-14-22)8-7-9-25(36)3 4-32(2,3)31(40)33-16-17-35(4)5/h10-15,19,26-30,37-39H,7-9, 16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30-/m1/s1
Isitshixo se-InChi:
BNPZTRDIESRGTC-IXYVTWBDSA-N
Igama elingundoqo:
LX-2761, LX2761, LX 2761, 1610954-97-6
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-LX2761 yi-inhibitor ye-SGLT1 esebenza kwingingqi enamandla kakhulu kwi-vitro kwaye ilibazise ukufakwa kwe-glucose emathunjini kwi-vivo ukuphucula ulawulo lwe-glycemic. I-LX2761 ine-hSGLt1 2.2 nM; hSGLT2 2.7 nM kunye F% =<2. I-LX2761 inamandla kakhulu, i-chemicals stable, kunye ne-luminally limited molecule ephumelele ubungqina bengcamango kwi-OGTT kwiidosi eziphantsi kakhulu. I-LX2761 yenzelwe ukuba ihlale emathunjini emva kokunikezelwa komlomo ukuze inqanda i-SGLT1 kwindawo ngaphandle kokuchaphazela indlela ye-SGLT1/2 kwizintso.
Ithagethi: SGLT1
