I-BAY-1895344
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 10mg | Ikhona evenkileni | 210 |
| 100mg | Ikhona evenkileni | 480 |
| 1g | Ikhona evenkileni | 950 |
Igama leMchiza:
(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine
Ikhowudi yoncumo:
CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl
Ikhowudi ye-InChi:
InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-20(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25) ;1H/t13-;/m1./s1
Isitshixo se-InChi:
KWQNBYGUBHMRPY-BTQNPOSSSA-N
Igama elingundoqo:
1876467-74-1;CAS:1876467-74-1;CAS:1876467-74-1;BAY-1895344, BAY1895344, BAY 1895344
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-BAY-1895344 i-ATR ekhethiweyo (i-ataxia-telangiectasia kunye ne-protein ehambelana ne-Rad3) inhibitor evimbela ukwanda kwe-spectrum ebanzi yemigca yeseli ye-tumor (median IC50 = 78 nM). I-BAY-1895344 iphuhliselwe ukunyanga izigulana ezinamathumba aqinileyo kunye ne-lymphomas, kwaye iphantsi kovavanyo lwenqanaba loku-I lokhuseleko kunye nokunyamezela kwizigulana ezinomhlaza.
Ithagethi: ATR