STING agonisti-4

Kimyoviy nomi:

1,1'-(butan-1,4-diyl)bis(2-(1-etil-3-metil-1H-pirazol-5-karboksamido)-1H-benzo[d]imidazol-5-karboksamid)

SMILE kodi:

O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC) (C)=NN6CC)=O)=NC2=C1)N

InChi kodi:

InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23-17-21(29(35)47)9-11- 25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)48)18-24(26)38-34(44)40-32(50) 28-16-20(4)42-46(28)6-2/h9-12,15-18H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36, 48)(H,37,39,49)(H,38,40,50)

InChi kaliti:

ICZSAXDKFXTSGL-UHFFFAOYSA-N

Kalit so'z:

Eruvchanligi: 

Saqlash: 

Tavsif:

STING agonisti-4 interferon genlari (STING) retseptorlari agonistlarining stimulyatori bo'lib, 20 nM ko'rinadigan inhibitiv doimiy (IC50) bilan. STING agonisti-4 - bu ikkita simmetriyaga bog'liq bo'lgan amidobenzimidazol (ABZI) asosidagi birikma bo'lib, STING va hujayra funktsiyasi bilan bog'langan ABZI (diABZI) hosil qiladi.

Maqsad: STING