| CAT # | Mahsulot nomi | Tavsif |
| CPD3611 | SB-204990 | SB-204990 kuchli ATP sitrat-liyaza inhibitori SB-201076 ning oldingi dorisidir. SB-204990, kalamushlarga og'iz orqali yuborilganda, tizimli qon aylanish tizimiga so'riladi, SB-201076 ning farmakologik jihatdan tegishli konsentratsiyalari jigarda topiladi. SB-204990 (kuniga 25 mg/kg) shuningdek, itda plazma xolesterin darajasini (23% gacha) va triglitseridlar darajasini (38% gacha) pasaytirdi, yuqori zichlikdagi lipoprotein xolesterin bilan solishtirganda past zichlikdagi lipoproteinni afzal ko'radi. darajalari. SB-204990 lipid sintezi uchun substrat ta'minotini nazorat qilishda muhim ferment va hipolipidemik aralashuv uchun potentsial ferment maqsadi hisoblanadi. |
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