| CAT # | Mahsulot nomi | Tavsif |
| CPD3233 | AZD-3409 | AZD-3409 kuchli prenil transferaza inhibitori. AZD-3409 lonafarnibga qaraganda yuqori quvvatni ko'rsatdi. AZD3409 ning sitotoksikligi uchun o'rtacha IC (50) mos ravishda MEF hujayralarida 510, A549 hujayralarida 10,600 va MCF7 hujayralarida 6,170 edi. Ushbu hujayralarda AZD3409 ning FTase faolligi uchun IC (50) 3,0 dan 14,2 nM gacha va lonafarnib 0,26 dan 31,3 nM gacha bo'lgan. AZD3409 geranilgeranilatsiyaga qaraganda farnesilatsiyani yuqori darajada inhibe qiladi. Farnesillanish va geranilgeranilatsiyani inhibe qilish ham preparatning antiproliferativ faolligi bilan bog'liq bo'lishi mumkin emas. AZD3409 gefitinibga chidamli ko'krak karsinomasida faol bo'lishi mumkin. |
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