Lyuksdegalutamid; ARV-766

Kimyoviy nomi:

4-(4-((1-(4-((1r,3r)-3-(4-siyano-3-metoksifenoksi)-2,2,4,4-tetrametilsiklobutil)karbamoil)p henil)piperidin-4-il)metil)piperazin-1-il)-N-((S)-2,6-dioksopiperidin-3-il)-2-ftorbenzamid

SMILE kodi:

CC1(C)[C@H](NC(C2=CC=C(N3CCC(CN4CCN(C5=CC(F)=C(C(N[C@@H)6C(=O)NC(=O) CC6)=O)C=C5)CC4)CC3)C=C2)=O)C(C)(C)[C@H]1OC1=CC(OC)=C(C#N)C=C1

InChi kodi:

InChI=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)5 8-5)50-39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-) 21-51) 32-11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28, 36,42-43H,14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42-,43-/m0 /s1

InChi kaliti:

RDPPBRKNBBXPNZ-FMPIRMQTSA-N

Kalit so'z:

2750830-09-0；CAS: 2750830-09-0;CAS: 2750830-09-0；ARV766; ARV 766; ARV-766; GTPL12624; lyuksdegalutamid

Eruvchanligi: 

Saqlash:Quruq, qorong'i va qisqa muddatli (kunlardan haftalargacha) 0 - 4 C yoki uzoq muddatli (oylar va yillar) uchun -20 C da.

Tavsif:

Lyuksdegalutamid (ARV-766) AR qarshiligi bilan bog'liq mutantlarni pasaytirishi mumkin bo'lgan androgen retseptorlari (AR) ga yo'naltirilgan, og'iz orqali samarali oqsil gidroliziga qaratilgan kimerik (PROTAC) hisoblanadi.

Maqsad: AR