Rivicclib

Jina la Kemikali:

2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hidrokloridi

Msimbo wa SMILES:

O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

Msimbo wa InChi:

InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-) 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

Ufunguo wa InChi:

OOVTUOCTLAERQD-OJMBIDBESA-N

Neno muhimu:

P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

Umumunyifu: 

Hifadhi: 

Maelezo:

Riviciclib, pia inajulikana kama P276-00, ni kizuizi kinachotegemea flavone na cyclin kinase (CDK) chenye uwezo wa kufanya shughuli za antineoplastiki. P276-00 hufunga kwa kuchagua na kuzuia Cdk4/cyclin D1, Cdk1/cyclin B na Cdk9/cyclin T1, serine/threonine kinase ambazo hutekeleza majukumu muhimu katika udhibiti wa mzunguko wa seli na kuenea kwa seli. Kuzuiwa kwa kinasi hizi husababisha kukamatwa kwa mzunguko wa seli wakati wa mabadiliko ya G1/S, na hivyo kusababisha kuanzishwa kwa apoptosis, na kuzuia kuenea kwa seli za tumor.

Lengo: CDK