Voruciclib

Lebitso la lik'hemik'hale:

2-(2-Chloro-4-(trifluoromethyl)phenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-1-benzopyran -4-e le 'ngoe

SMILES Khouto:

O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@H]4[C@H](CO)N(C)CC4)C (O)=CC(O)=C13

Khoutu ea InChi:

InChI=1S/C22H19ClF3NO5/c1-27-5-4-12(14(27)9-28)19-15(29)7-16(30)20-17(31)8-18(32-21( 1 9)20)11-3-2-10(6-13(11)23)22(24,25)26/h2-3,6-8,12,14,28-30H,4-5,9H2, 1H3/t12-,14+/m1/s1

InChi Key:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Keyword:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Sollubility: 

Polokelo: 

Tlhaloso:

Voruciclib, eo hape e tsejoang e le P1446A-05, ke protheine kinase inhibitor e khethehileng bakeng sa cyclin-dependent kinase 4 (CDK4) e nang le ts'ebetso e ka bang teng ea antineoplastic. CDK4 inhibitor P1446A-05 ka ho khetheha e thibela phetoho ea mohato oa CDK4-mediated G1-S, ho tšoara libaesekele tsa sele le ho thibela kholo ea lisele tsa mofetše. CDK4 ea serine / threonine kinase e fumanoa ka mokhoa o rarahaneng o nang le li-cyclins tsa mofuta oa D-mofuta oa G1 'me ke kinase ea pele e sebelisoang holim'a ts'usumetso ea mitogenic, e lokolla lisele ho tloha sethaleng se khutsitseng ho ea sethaleng sa G1 / S sa baesekele ea kholo; Li-CDK-cyclin complexes li bontšitsoe ho phosphorylate the retinoblastoma (Rb) transcription factor qalong ea G1, ho tlosa histone deacetylase (HDAC) le ho thibela khatiso ea transcriptional.

Sepheo: CDK4