THZ531
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4- (dimethylamino) empa-2-enamide
SMILES Khouto:
"O=C(NC1=CC=C(C(N2C[C@H](NC3=NC=C(Cl)C(C4=CNC5=C4C=CC=C5)=N3)CCC2)=O)C= C1)/C=C/CN(C)C "
Khoutu ea InChi:
InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7- 22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4, 6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34,39)(H,33,35,36)/b10-6+/ t22-/m1/s1
InChi Key:
RUBYHLPRZRMTJO-MOVYNIQHSA-N
Keyword:
THZ-531, THZ 531, THZ531, 1702809-17-3
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
THZ531 ke covalent CDK12 le CDK13 covalent inhibitor. Cyclin-dependent kinases 12 le 13 (CDK12 le CDK13) li bapala karolo ea bohlokoa taolong ea ho ngoloa ha liphatsa tsa lefutso. THZ531 e shebile ka mokhoa o sa fetoheng cysteine e fumanehang kantle ho sebaka sa kinase. THZ531 e baka tahlehelo ea polelo ea liphatsa tsa lefutso ka tahlehelo e ts'oanang ea ho lelefatsa le hyperphosphorylated RNA polymerase II. THZ531 e fokotsa haholo polelo ea liphatsa tsa lefutso tsa tšenyo ea DNA le liphatsa tsa lefutso tse amanang le "super-enhancer-associated transcription factor". THZ531 e bakile lefu la lisele tsa apoptotic haholo. Limolek'hule tse nyane tse khonang ho shebana le CDK12 le CDK13 ka ho khetheha li ka thusa ho tseba mefuta ea mofetše e itšetlehileng haholo ka mesebetsi ea bona ea kinase.
Sepheo: CDK
