Alvocidib
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Lebitso la lik'hemik'hale:
2-(2-chlorophenyl)-5,7-dihydroxy-8-((3R,4S)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one
SMILES Khouto:
O=C1C=C(C2=CC=CC=C2Cl)OC3=C([C@H]4[C@@H](O)CN(C)CC4)C(O)=CC(O)=C13
Khoutu ea InChi:
InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21( 19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17 +/m1/s1
InChi Key:
BIIVYFLTOXDAOV-PXAZEXFGSA-N
Keyword:
L 86-8275; L-868275; L 868275; L868275; HMR 1274; HMR-1274; HMR1274; Flavoperidol; Alvocidib
Sollubility:
Polokelo:
Tlhaloso:
Alvocidib ke motsoako oa maiketsetso oa N-methylpiperidinyl chlorophenyl flavone. Joalo ka inhibitor ea cyclin-dependent kinase, alvocidib e etsa hore ho ts'oaroe ha cell cycle ka ho thibela phosphorylation ea cyclin-dependent kinases (CDKs) le ka ho theola taolo ea cyclin D1 le polelo ea D3, e fellang ka ho ts'oaroa ha lisele tsa G1 le apoptosis. Moemeli ona hape ke inhibitor ea tlholisano ea ts'ebetso ea adenosine triphosphate. Sheba liteko tse sebetsang tsa tleliniki kapa liteko tse koetsoeng tsa bongaka u sebelisa moemeli enoa.
Sepheo: CDK