MSC2530818
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 400 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
[(2S)-2-(4-Chlorophenyl)pyrrolidin-1-yl]-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)methanone
SMILES Khouto:
O=C(N1[C@H](C2=CC=C(Cl)C=C2)CCC1)C3=CN=C(NN=C4C)C4=C3
Khoutu ea InChi:
InChI=1S/C18H17ClN4O/c1-11-15-9-13(10-20-17(15)22-21-11)18(24)23-8-2-3-16 (23)12-4-6-14(19)7-5-12/h4-7,9-10,16H,2-3,8H2,1H3,(H,20,21,22)/t16-/ m0/s1
InChi Key:
ODRITQGYYWHQGM-INIZCTEOSA-N
Keyword:
MSC2530818, MSC-2530818, MSC 2530818, 1883423-59-3
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
MSC2530818 ke CDK8 Inhibitor e Matla, e Khethollang, le ea Molomo e nang le CDK8 IC50 = 2.6 nM; Polelo ea PK ea Motho: Cl ~ 0.14 L/H/Kg; t1/2 ~ 2.4h; F > 75%. MSC2530818 e bonts'a khetho e ntle haholo ea kinase, biochemical le cellular potency, microsomal stability, mme e fumaneha ka molomo. MSC2530818 e bonts'a potency e loketseng le khetho ea ho tsoela pele ho ba lithuto tsa pele tsa katleho le polokeho ea vivo.
Sepheo: CDK
