SEL120-34A

Lebitso la lik'hemik'hale:

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride

SMILES Khouto:

CC1=C(Br)C(Br)=C2CCCN3C2=C1N=C3N4CCNCC4.[H]Cl

Khoutu ea InChi:

InChI=1S/C15H18Br2N4.ClH/c1-9-11(16)12(17)10-3-2-6-21-14(10)13(9)19-15(21)20-7-4- 18-5-8-20;/h18H,2-8H2,1H3;1H

InChi Key:

GQXLWUCQESKBSC-UHFFFAOYSA-N

Keyword:

SEL120-34A; SEL 120-34A; SEL-120-34A; SEL12034A; SEL 12034A; SEL-12034A

Sollubility: 

Polokelo: 

Tlhaloso:

SEL120-34A ke CDK8 inhibitor e matla le e khethang e sebetsang liseleng tsa AML tse nang le maemo a phahameng a serine phosphorylation ea STAT1 le STAT5 transactivation domains. EL120-34A e thibela phosphorylation ea STAT1 S727 le STAT5 S726 liseleng tsa mofetše ka vitro. Ka mokhoa o ts'oanang, taolo ea STATs- le NUP98-HOXA9- e itšetlehileng ka transcript e 'nile ea hlokomeloa e le mokhoa o ka sehloohong oa ts'ebetso ka vivo.

Sepheo: CDK8