LDC000067

Lebitso la lik'hemik'hale:

3-[[6-(2-Methoxyphenyl)-4-pyrimidinyl]amino]benzenemethanesulfonamide

SMILES Khouto:

O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O

Khoutu ea InChi:

InChI=1S/C18H18N4O3S/c1-25-17-8-3-2-7-15(17)16-10-18(21-12-20-16)22-14-6 -4-5-13(9-14)11-26(19,23)24/h2-10,12H,11H2,1H3,(H2,19,23,24)(H,20,21,22)

InChi Key:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Keyword:

LDC000067; LDC-000067; LDC 000067

Sollubility: 

Polokelo: 

Tlhaloso:

LDC000067 ke inhibitor e matla le e khethang ea CDK9. LDC000067 e thibetsoe ho ngoloa ka har'a vitro ka mokhoa oa tlholisano oa ATP le o itšetlehileng ka tekanyo. Tlhaloso ea liphatsa tsa lefutso ea lisele tse tšoaroang ka LDC000067 e bonts'itse phokotso e ikhethileng ea li-mRNA tsa nakoana, ho kenyelletsa le balaoli ba bohlokoa ba ho ata le apoptosis. Tlhahlobo ea de novo RNA synthesis e khothalelitse karolo e fapaneng e ntle ea CDK9. Boemong ba limolek'hule le liselefouno, LDC000067 e hlahisitse litlamorao tsa thibelo ea CDK9 joalo ka khefutso e ntlafalitsoeng ea RNA polymerase II liphatseng tsa lefutso, 'me haholo-holo, ho kenngoa ha apoptosis liseleng tsa mofetše. LDC000067 e thibela ho ngoloa ha P-TEFb e itšetlehileng ka in vitro. E kenya apoptosis in vitro le in vivo hammoho le BI 894999.

Sepheo: CDK9