Rivicclib

Rivicclib
  • Lebitso:Rivicclib
  • Nomoro ea lethathamo:CPD100907
  • Nomoro ea CAS:920113-03-7 (HCl) 920113-02-6 (sebaka sa mahala)
  • Boima ba Molek'hule:401.103
  • Foromo ea Lik'hemik'hale:C21H21Cl2NO5
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    Lebitso la lik'hemik'hale:

    2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

    SMILES Khouto:

    O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H] Cl

    Khoutu ea InChi:

    InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28- 21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12 -,14+;/m1./s1

    InChi Key:

    OOVTUOCTLAERQD-OJMBIDBESA-N

    Keyword:

    P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

    Sollubility: 

    Polokelo: 

    Tlhaloso:

    Riviciclib, e tsejoang hape e le P276-00, ke inhibitor ea flavone le cyclin dependent kinase (CDK) e nang le ts'ebetso e ka bang teng ea antineoplastic. P276-00 e khetha ho tlama le ho thibela Cdk4 / cyclin D1, Cdk1 / cyclin B le Cdk9 / cyclin T1, serine / threonine kinases e phethang karolo ea bohlokoa taolong ea potoloho ea lisele le ho ata ha lisele. Ho thibela li-kinase tsena ho lebisa ho ts'oaroe ha potoloho ea lisele nakong ea phetoho ea G1 / S, ka hona ho lebisa ho induction ea apoptosis, le ho thibela ho ata ha lisele tsa tumor.

    Sepheo: CDK


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