CB-839
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol -2-yl) acetamide
SMILES Khouto:
O=C(NC1=CC=C(CCCCC2=NN=C(NC(CC3=NC=CC=C3)=O)S2)N=N1)CC4=CC(OC(F)(F)F)=CC =C4
Khoutu ea InChi:
InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34- 21)7-1-2-10-24- 35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7, 10,15-16H2,(H,31,34,37)(H,32,36,38)
InChi Key:
PRAAPINBUWJLGA-UHFFFAOYSA-N
Keyword:
CB-839, CB839, CB 839, 1439399-58-2
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
"CB-839 an is orally bioavailable inhibitor of glutaminase, e nang le ts'ebetso e ka 'nang ea e-ba antineoplastic. Ha e sebelisoa ka molomo, CB-839 e thibela ka mokhoa o ikhethileng le ka mokhoa o ke keng oa fetoloa, e leng enzyme ea mitochondrial e hlokahalang bakeng sa phetoho ea amino acid glutamine Ka ho thibela glutamine. ho sebelisoa, ho ata ha lisele tse hōlang ka potlako Lihlahala tse itšetlehileng ka Glutamine li itšetlehile ka phetoho ea glutamine e tsoang linaheng tse ling hore e be glutamate le metabolites ea glutamate ho fana ka matla le ho hlahisa li-macromolecules, tse hlokahalang bakeng sa kholo ea cellular le ho phela.
Sepheo: Glutaminase
