BS-181

Lebitso la lik'hemik'hale:

N5-(6-aminohexyl)-N7-benzyl-3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diamine hydrochloride

SMILES Khouto:

CC(C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1)C.[H]Cl

Khoutu ea InChi:

InChI=1S/C22H32N6.ClH/c1-17(2)19-16-26-28-21(25-15-18-10-6-5-7-11-18)14-20(27-22( 19) 28 )24-13-9-4-3-8-12-23;/h5-7,10-11,14,16-17,25H,3-4,8-9,12-13,15,23H2, 1-2H3,(H,24,27);1H

InChi Key:

NVIJWMOQODWNFN-UHFFFAOYSA-N

Keyword:

Sollubility: 

Polokelo: 

Tlhaloso:

BS-181 ke CDK inhibitor e khethang haholo bakeng sa CDK7 e nang le IC(50) ea 21 nmol/L. Liteko tsa li-CDK tse ling hammoho le li-kinase tse ling tse 69 li bonts'itse hore BS-181 e thibela CDK2 feela maemong a tlase ho 1 micromol/L, 'me CDK2 e thibetsoe ka makhetlo a 35 ka matla (IC(50) 880 nmol/L) ho feta CDK7. Liseleng tsa MCF-7, BS-181 e thibetse phosphorylation ea li-substrates tsa CDK7, e khothalelitse ho ts'oaroa ha potoloho ea lisele le apoptosis ho thibela kholo ea lisele tsa mofetše, mme e bonts'a litlamorao tsa antitumor ho vivo.

Sepheo: CDK7