GSK2982772
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(S) -5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl) -4H-1,2, 4-triazole-3-carboxamide
SMILES Khouto:
O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O
Khoutu ea InChi:
InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(2 3-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24) /t14-/m0/s1
InChi Key:
LYPAFUINURXJSG-AWEZNQCLSA-N
Keyword:
GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
GSK2982772 ke mokelikeli o matla le o khethang o sebelisanang le Protein 1 (RIP1) Kinase Specific Clinical Candidate bakeng sa Phekolo ea Maloetse a Runyang. GSK2982772, hajoale e mokhahlelong oa 2a oa lithuto tsa bongaka bakeng sa psoriasis, ramatiki ea ramatiki le lefu la ho ruruha ha mala. GSK2982772 e tlamella ho RIP1 ka mokhoa o hlakileng oa kinase mme e na le ts'ebetso e ntle haholo ho thibela likarabo tse ngata tsa cellular tse itšetlehileng ka TNF. RIP1 e hlahile e le kinase ea bohlokoa e holimo e bontšitsoeng ho laola ho ruruha ka mesebetsi e khethehileng ea scaffolding le kinase.
Sepheo: RIP1
