BLU-285
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 1g | E teng thepeng e teng ka lebenkeleng | 900 |
| 5g | E teng thepeng e teng ka lebenkeleng | 3600 |
| 10g | E teng thepeng e teng ka lebenkeleng | 6200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4 ]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine
SMILES Khouto:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@]](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
Khoutu ea InChi:
InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)2 4-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2, 1-2H3/t26-/m0/s1
InChi Key:
DWYRIWUZIJHQKQ-SANMLTNESA-N
Keyword:
BLU-285, BLU 285, BLU285, Avapritinib
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
Avapritinib (BLU-285) e bontšitse tšebetso ea biochemical in vitro ho KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Ts'ebetso ea cellular ea Avapritinib ho liphetoho tsa KIT D816 e lekantsoe ka autophosphorylation ho human mast cell leukemia cell line HMC1.2, le P815 mouse mastocytoma cell line le IC50=4 le 22 nM, ka ho latellana. Ka liseleng tsa Kasumi-1, ho(8;21) -positive AML cell line e nang le phetoho ea KIT exon 17 N822K, Avapritinib e thibela ka matla KIT N822K mutant autophosphorylation (IC50=40 nM), pontšo e tlase, hammoho le ho ata ha cellular (IC50= 75 nM)[1].
Sepheo: KIT
