GDC-0077

GDC-0077
  • Lebitso:GDC-0077
  • Nomoro ea lethathamo:CPDB1573
  • Nomoro ea CAS:2060571-02-8
  • Boima ba Molek'hule:407.37
  • Foromo ea Lik'hemik'hale:C18H19F2N5O4
  • Bakeng sa lipatlisiso tsa saense feela, eseng bakeng sa bakuli.

    Lintlha tsa Sehlahisoa

    Li-tag tsa Sehlahisoa

    Boholo ba Pakete Ho fumaneha Theko (USD)
    100mg E teng thepeng e teng ka lebenkeleng 500
    500mg E teng thepeng e teng ka lebenkeleng 800
    1g E teng thepeng e teng ka lebenkeleng 1200
    Boholo bo Eketsehileng Fumana Litlhaloso Fumana Litlhaloso

    Lebitso la lik'hemik'hale:

    (S) -2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)amino)propanamide

    SMILES Khouto:

    C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

    Khoutu ea InChi:

    InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21 ,26)/t9-,12-/m0/s1

    InChi Key:

    SGEUNORSOZVTOL-CABZTGNLSA-N

    Keyword:

    GDC-0077, GDC0077, GDC 0077, 2060571-02-8

    Sollubility:E qhibiliha ka DMSO

    Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).

    Tlhaloso:

    GDC-0077 ke PI3K inhibitor e fumanehang ka molomo le e khethang (IC50 = 0.038 + 0.003 nM) e nang le> 300-fold khethang ho feta tse ling tsa Class I PI3K isoforms. GDC-0077 e etsa mosebetsi oa eona ka ho tlama sebakeng sa ATP se tlamang sa PI3K, kahoo e thibela phosphorylation ea PIP2 ho PIP3.

    Sepheo: PI3K


  • E fetileng:
  • E 'ngoe:

  • Lihlahisoa tse Amanang

    .
    Moqoqo oa Marang-rang oa WhatsApp!