Derazantinib; ARQ-087
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 10mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 100mg | E teng thepeng e teng ka lebenkeleng | 1200 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 1800 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine
SMILES Khouto:
COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1
Khoutu ea InChi:
InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24- 10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13- 16,18H2,1H3,(H,32,33,34)/t26-/m1/s1
InChi Key:
KPJDVVCDVBFRMU-AREMUKBSSA-N
Keyword:
Derazantinib, ARQ-087, ARQ087, ARQ 087, 1234356-69-4
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
Derazantinib, e tsejoang hape e le ARQ-087, ke inhibitor ea molomo ea bioavailable ea fibroblast growth factor receptor (FGFR) e nang le ts'ebetso e ka bang teng ea antineoplastic. FGFR inhibitor ARQ 087 e tlama le ho thibela ka mokhoa o matla mosebetsi oa FGFR subtypes 1, 2 le 3. Sena se ka 'na sa fella ka ho thibela litsela tsa ho fetisetsa lipontšo tsa FGFR, ho ata ha lisele tsa tumor, angiogenesis ea tumor le lefu la lisele tsa tumor ho FGFR-overexpressing lisele tsa tumor. . FGFR, receptor tyrosine kinase, e laoloa ka mefuta e mengata ea lisele tsa tumor 'me e phetha karolo ea bohlokoa ho ata ha lisele tsa tumor, ho arohana, angiogenesis le ho pholoha.
Sepheo: FGFR
