GSK2256098
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 450 |
| 1g | E teng thepeng e teng ka lebenkeleng | 2000 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
2-(5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide
SMILES Khouto:
CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C
Khoutu ea InChi:
InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22 -18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23) , 24)
InChi Key:
BVAHPPKGOOJSPU-UHFFFAOYSA-N
Keyword:
GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
GSK2256098, eo hape e tsejoang ka hore ke GTPL7939, ke inhibitor ea focal kinase-1 (FAK) e nang le mesebetsi e ka bang teng ea antiangiogenic le antineoplastic. FAK inhibitor GSK2256098 e thibela FAK, e ka thibelang ts'ebetso ea integrin-mediated ea litsela tse 'maloa tsa ho fetisetsa matšoao a tlaase, ho akarelletsa le ERK, JNK/MAPK le PI3K/Akt, kahoo e thibela ho falla ha lisele tsa tumor, ho ata le ho phela, le tumor angiogenesis. tyrosine kinase FAK hangata e kengoa tšebetsong ka ho tlama li-integrin ka har'a matrix a extracellular (ECM) empa e ka laoloa le ho kengoa tšebetsong ka mokhoa o ikhethileng mefuteng e fapaneng ea lisele tsa tumor.
Sepheo: FAK