EED226
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 25mg | E teng thepeng e teng ka lebenkeleng | 300 |
| 50mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 100mg | E teng thepeng e teng ka lebenkeleng | 800 |
Lebitso la lik'hemik'hale:
N-(furan-2-ylmethyl) -8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
SMILES Khouto:
O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
Khoutu ea InChi:
InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)
InChi Key:
DYIRSNMPIZZNBK-UHFFFAOYSA-N
Keyword:
EED226, EED-226, EED 226, 2083627-02-3
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
EED226 ke inhibitor e matla haholo, e sebetsang hantle le e khethang ea EZH2 le EZH1 e hlahlojoang khahlanong le mefuta e mengata ea sepheo sa epigenetic le e seng epigenetic. E fokotsa ka mokhoa o hlakileng letšoao la lefats'e la H3K27Me3 liseleng mme e bonts'a litlamorao tsa ho bolaea lisele ka mokhoa o ikhethileng liseleng tse nang le phetoho ea heterozygous Y641N. EED226 e na le ho kenella ka mokhoa o itekanetseng joalo ka ha ho lekantsoe liseleng tsa Caco-2 ho A→ B=3.0x10-6 cm/s, ka karolelano ea efflux ho 7.6[1].
Sepheo: EED226
