Bardoxolone methyl

Lebitso la lik'hemik'hale:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

SMILES Khouto:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Khoutu ea InChi:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

InChi Key:

WPTTVJLTNAWYAO-OROHISIGSA-N

Keyword:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)

Tlhaloso:

The synthetic oleanane triterpenoid CDDO (Item No. 81035) ke Nrf2 activator e thibelang ho ata le ho etsa hore ho be le phapang le apoptosis lisele tse sa tšoaneng tsa kankere. C-28 methyl ester ea CDDO (CDDO methyl ester) e thibela motsoako oa cellular oa inducible nitric oxide synthase (iNOS) le inducible COX-2 ho INF-γ-activated mouse macrophages ka IC50 bohlokoa ba 0.11 nM. E etsa hore ho be le apoptosis, e etsa hore ho be le phapang, 'me e thibela karabelo ea ho ruruha liseleng tse sa tšoaneng tsa tumor ka ho thibela pontšo ea IκBα kinase/NF-κB. CDDO methyl ester e na le ts'ebetso e matla ea antidiabetic, e fokotsang polelo ea proinflammatory cytokine ho litoeba tsa mofuta oa 2 oa lefu la tsoekere le ho Leprdb / db litoeba le ho kenya tšebetsong AMP-activated protein kinase le LKB1 activation mesifa le sebete.

Sepheo: NF-kB