CP-456773 sodium
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)(4-(2-hydroxypropan-2-yl)furan-2-yl)sulfonyl)amide
SMILES Khouto:
O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
Khoutu ea InChi:
InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q; +1/p-1
InChi Key:
LFQQNXFKPNZRFT-UHFFFAOYSA-M
Keyword:
MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 letsoai la sodium, Cytokine tokollo inhibitory drug 3, 256373-96
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
CP-456773, eo hape e tsejoang e le MCC950 le CRID3, ke cytokine release inhibitor e matla le e khethang le NLRP3 inflammasome inhibitor bakeng sa phekolo ea mafu a ho ruruha. CP-456773 e thibela secretion ea interleukin 1β (IL-1β) le ts'ebetso ea caspase 1. MCC950 e thibetse ts'ebetso ea canonical le e seng ea noncanonical NLRP3 maemong a nanomolar. MCC950 e thibetse ka ho khetheha ts'ebetso ea NLRP3 empa eseng AIM2, NLRC4 kapa NLRP1 inflammasomes. MCC950 e fokolitse tlhahiso ea interleukin-1β (IL-1β) ka har'a vivo le ho fokotsa boima ba liteko tsa autoimmune encephalomyelitis (EAE), mohlala oa lefu la multiple sclerosis. MCC950 ke phekolo e ka 'nang ea e-ba teng bakeng sa li-syndromes tse amanang le NLRP3, ho kenyelletsa le mafu a autoimmune le a autoimmune, le sesebelisoa sa ho tsoela pele ho ithuta NLRP3 inflammasome bophelong ba batho le maloetse.
Sepheo: NLRP3
