Batefenterol

Lebitso la lik'hemik'hale:

"(R) -1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino) methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"

SMILES Khouto:

O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

Khoutu ea InChi:

InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10- 6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1

InChi Key:

URWYQGVSPQJGGB-DHUJRADRSA-N

Keyword:

Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6

Sollubility:E qhibiliha ka DMSO

Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli)

Tlhaloso:

Batefenterol ke mohanyetsi oa muscarinic le β2-adrenergic receptor (β2-AR) agonist (Kis = 1.4, 1.3, le 3.7 nM, bakeng sa hM2, hM3, le hβ2-AR, ka ho latellana tekong e tlamang ea radioligand). Batefenterol e bonts'a ts'ebetso e matla ea agonist ea hβ2-AR (EC50 = 0.29 nM) e nang le 440- le 320-fold functional selectivity holim'a hβ1- le hβ3-ARs, ka ho latellana.1 Batefenterol e etsa hore mesifa e phutholohe e boreleli (EC50 = 11 nM) sebakeng se ka thōko sa tracheal Guinea lisele le ho thibela karabelo ea bronchoconstrictor tekong ea ho itšireletsa mafung (ED50 = 6.4 µg/mL). Meetso e nang le batefenterol e litekong tsa bongaka tsa ho phekola lefu le sa foleng la matšoafo (COPD).

Sepheo: β2-adrenoceptor