LX-2761
Lintlha tsa Sehlahisoa
Li-tag tsa Sehlahisoa
| Boholo ba Pakete | Ho fumaneha | Theko (USD) |
| 100mg | E teng thepeng e teng ka lebenkeleng | 500 |
| 500mg | E teng thepeng e teng ka lebenkeleng | 800 |
| 1g | E teng thepeng e teng ka lebenkeleng | 1200 |
| Boholo bo Eketsehileng | Fumana Litlhaloso | Fumana Litlhaloso |
Lebitso la lik'hemik'hale:
N-(1-((2-(Dimethylamino)ethyl)amino)-2-methyl-1-oxopropan-2-yl)-4-(4-(2-methyl-5-((2S,3R,4R), 5S,6R) -3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)benzyl)phenyl) -butanamide
SMILES Khouto:
O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3)=CC=C2C)C=C1
Khoutu ea InChi:
InChI=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21(12-14-22)8-7-9-25(36)3 4-32(2,3)31(40)33-16-17-35(4)5/h10-15,19,26-30,37-39H,7-9, 16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30-/m1/s1
InChi Key:
BNPZTRDIESRGTC-IXYVTWBDSA-N
Keyword:
LX-2761, LX2761, LX 2761, 1610954-97-6
Sollubility:E qhibiliha ka DMSO
Polokelo:0 - 4 ° C bakeng sa nako e khutšoanyane (matsatsi ho isa libeke), kapa -20 ° C bakeng sa nako e telele (likhoeli).
Tlhaloso:
LX2761 ke SGLT1 inhibitor e sebetsang sebakeng sa heno e matla haholo ka har'a vitro mme e liehisa ho monya ha tsoekere ka har'a vivo ho ntlafatsa taolo ea glycemic. LX2761 e na le hSGLt1 2.2 nM; hSGLT2 2.7 nM le F% =<2. LX2761 ke molek'hule e matla haholo, e tsitsitseng lik'hemik'hale, 'me e thibetsoe ka mokhoa o khanyang e fihletseng bopaki ba mohopolo ho OGTT ka litekanyetso tse tlase haholo. LX2761 e ne e etselitsoe hore e lule ka maleng ka mor'a ho pepa ka molomo ho thibela SGLT1 sebakeng sa heno ntle le ho ama mochine oa SGLT1/2 liphio.
Sepheo: SGLT1
