Bardoxolone methyl

Magaca Kiimikada:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS) -methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Koodhka dhoola cadeynta:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C (C)C3=C5=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Koodhka InChi:

InChi=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29 (5) 16-19 (18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

Furaha InChi:

WPTTVJLTNAWYAO-OROHISIGSA-N

Ereyga muhiimka ah:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

Sharaxaad:

Oleanane triterpenoid CDDO synthetic (Shayga No. 81035) waa firfircooni Nrf2 kaas oo joojiya faafitaanka wuxuuna keenaa kala duwanaansho iyo apoptosis unugyada kansarka kala duwan. C-28 methyl ester ee CDDO (CDDO methyl ester) waxay xannibaysaa isku-dhafka unugga ee nitric oxide synthase (iNOS) iyo COX-2 oo aan la dabooli karin oo ku jira INF-γ-firfircooni macrophages oo leh IC50 qiimaha 0.11 nM. Waxay kicisaa apoptosis, waxay keentaa kala duwanaansho, waxayna joojisaa jawaabta bararka ee unugyada burooyinka kala duwan iyada oo la xakameynayo calaamadaha IκBα kinase / NF-κB. CDDO methyl ester waxay leedahay firfircooni antidiabetic oo awood leh, hoos u dhigista muujinta proinflammatory cytokine ee nooca dufanka badan ee la quudiyo nooca 2 jiirka macaanka iyo jiirka Leprdb / db iyo kicinta AMP-firfircoon ee kinase protein iyo firfircoonida LKB1 ee muruqa iyo beerka

Hadafka: NF-kB