| CAT # | Magaca Alaabta | Sharaxaada |
| CPD9470 | Obeticolic acid | Obeticholic Acid (INT747; 6-ECCDCA) waa soosaar cusub oo ka soo jeeda cholic acid kaas oo u shaqeeya sidii FXR agonist xoog leh oo door ah oo soo bandhigaya waxqabadka anticholeretic ee qaabka jiirka vivo ee cholestasis. Waxay ka hortagtaa caabuqa unugyada muruqyada siman ee xididdada dhiigga iyo socdaalka iyo sidoo kale waxay kor u qaaddaa kala duwanaanta adipocyte waxayna nidaamisaa shaqada unugyada adipose ee vivo. |
| CPD100579 | fexaramine | Fexaramine waa agonist ee farnesoid X reseptor (FXR), kaas oo ah xameetida firfircoon ee nukliyeerka ee xakameynaya isku dhafka bile-acid, isku dhafka iyo gaadiidka, iyo sidoo kale dheef-shiid kiimikaad iyada oo loo marayo falalka beerka iyo mindhicirka. Fexaramine waxay leedahay 100-laab xiriir ka weyn FXR marka loo eego xeryahooda dabiiciga ah waxayna ku qeexeen bartilmaameedyada genomic iyo goobta ku xiran ee FXR. Marka afka laga qaato jiirarka, fexaramine waxay soo saartay ficillo la xushay iyada oo loo marayo soo-dhoweynta FXR ee xiidmaha. |
| CPD100577 | Lithocholic acid | Levallorphan, oo sidoo kale loo yaqaano levallorphan tartate (USAN), waa habeeyaha opioid ee qoyska morphin ee loo isticmaalo sidii xanuunka opioid iyo opioid antagonist/antidote. Waxay u shaqeysaa sidii antagonist of μ-opioid reseptor (MOR) iyo sida agonist ee κ-opioid receptor (KOR), natiijadu, waxay xannibtaa saameynta wakiilada xooggan ee leh waxqabadyo gudaha ah sida morphine iyada oo isla mar ahaantaana soo saaraya xanuunka. . Sida agonist ee KOR, levallorphan wuxuu soo saari karaa dareen-celin maskaxeed oo daran qiyaaso ku filan oo ay ku jiraan riyooyin, aan caadi ahayn, iyo saameynaha kale ee cilmi-nafsiga, dysphoria, walaaca, jahawareer, dawakhaad, jaahwareer, niyad jab, dareenka sakhraannimada, iyo riyooyin yaab leh, aan caadi ahayn, ama qas. . (Isha: https://en.wikipedia.org/wiki/Levallorphan). |
| CPD100575 | Turofexorate-Isoropyl | Turofexorate isopropyl, oo sidoo kale loo yaqaan WAY-362450 iyo XL335, waa agonist aad u xoog badan, xulashada, iyo afka firfircoon ee farnesoid X receptor (FXR) (EC (50) = 4 nM, Eff = 149%), kaas oo yareeya caabuqa beerka. iyo fibrosis ee qaabka murineka ee steatohepatitis aan khamriga ahayn |
| CPD100574 | GW4064 | GW4064. |
| CPD1549 | Tropifexor | Tropifexor waa sheeko cusub oo awood sare leh oo FXR ah oo leh EC50 ee 0.2 nM. |
