Nazartinib; EGF816; NVS-816

Nazartinib; EGF816; NVS-816
  • Magaca:Nazartinib; EGF816; NVS-816
  • Lambarka buugga:CPDB3615
  • Lambarka CAS:"1508250-71-2"
  • Miisaanka Molecular:495.02
  • Foomka Kiimikada:C26H31ClN6O2
  • Cilmi baaris cilmiyeed oo keliya, ma ahan bukaanka.

    Faahfaahinta Alaabta

    Tags Product

    Cabbirka Xidhmada Helitaanka Qiimaha (USD)
    25mg In Stock 290
    50mg In Stock 450
    100mg In Stock 630
    1g In Stock 1600
    Cabiro badan Hel Xigasho Hel Xigasho

    Magaca Kiimikada:

    (R,E)-N-(7-chloro-1-(1--4- (dimethylamino)laakin-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl) 2-methylisonicotinamide

    Koodhka dhoola cadeynta:

    O=C(NC1=NC2=CC=CC(Cl)=C2N1[C@H]3CN(C(/C=C/CN(C)C)=O)CCCC3)C4=CC=NC(C)= C4

    Koodhka InChi:

    InChi=1S/C26H31ClN6O2/c1-18-16-19(12-13-28-18)25(35)30-26-29-22-10-6-9-21(27)24(22)33( 26)20-8-4-5-15-32(17-20)23(34)11-7-14-31(2)3/h6-7,9-13,16,20H,4-5, 8,14-15,17H2,1-3H3,(H,29,30,35)/b11-7+/t20-/m1/s1

    Furaha InChi:

    IOMMMLWIABWRKL-WUTDNEBXSA-N

    Ereyga muhiimka ah:

    Nazartinib, EGF816, EGF-816, EGF 816, NVS-816, 1508250-71-2

    Xalka:Ku milmay DMSO

    Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

    Sharaxaad:

    Nazartinib, oo sidoo kale loo yaqaan EGF816 iyo NVS-816, waa af laga heli karo, aan laga noqon karin, jiilka saddexaad, mutant-doortay korriinka koritaanka epidermal (EGFR), oo leh firfircoonida antineoplastic. EGF816 waxay si wada jir ah ugu xidhaa oo ay u joojisaa dhaqdhaqaaqa noocyada mutant ee EGFR, oo ay ku jiraan mutant T790M EGFR, si ay uga hortagto calaamadaynta dhexdhexaadinta EGFR. Tani waxay labadaba keeni kartaa dhimashada unugyada waxayna joojinaysaa korriinka burada ee unugyada burooyinka ee EGFR. EGF816 waxay si gaar ah u joojisaa qaababka isbeddelka ah ee EGFR oo ay ku jiraan T790M, isbeddelka iska caabbinta labaad ee la helay, waxaana laga yaabaa inay faa'iidooyin daweyn ku yeeshaan burooyinka leh T790M iska caabin dhexdhexaadin ah marka la barbar dhigo kuwa kale ee EGFR tyrosine kinase inhibitors.

    Hadafka: EGFR


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