MEK

CAT #	Magaca Alaabta	Sharaxaada
CPDB0157	BI-847325	BI-847325 waa dual la doortay MEK/Aurora kinase inhibitor oo leh IC50 qiimaha 3, 25, 15, 25, iyo 4 nM ee X. laevis Aurora B, aadanaha Aurora A iyo Aurora C, iyo aadanaha MEK1 iyo MEK2, siday u kala horreeyaan. Waxay joojin kartaa korriinka iyo badbaadada labadaba daawaynta-naive-ka iyo dawada u adkaysata xariiqyada unugyada melanoma, hoos u dhigista muujinta MEK iyo Mcl-1 iyadoo kordhinaysa muujinta borotiinka pro-apoptotic Bim. At 70 mg/kg, BI-847325 waxay keentaa apoptosis ee daawaynta-naive iyo daawada u adkaysata xenografted melanoma in vivo.