GSK2256098

Magaca Kiimikada:

2-((5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

Koodhka dhoola cadeynta:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

Koodhka InChi:

InChi=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8- 6-5-7-14 (16)20 (28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)

Furaha InChi:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Ereyga muhiimka ah:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

GSK2256098, oo sidoo kale loo yaqaan GTPL7939, waa focal adhesion kinase-1 (FAK) horjooge leh hawlo antiangiogenic iyo antineoplastic oo suurtagal ah. FAK inhibitor GSK2256098 waxay joojisaa FAK, taas oo laga yaabo inay ka hortagto dhaqdhaqaaqa dhexdhexaadinta dhexdhexaadka ah ee dhowr dariiqo gudbinta calaamadaha hoose, oo ay ku jiraan ERK, JNK/MAPK iyo PI3K/Akt, taas oo joojinaysa guuritaanka unugyada burooyinka, korodhka iyo badbaadada, iyo buro angiogenesis. tyrosine kinase FAK caadi ahaan waxa lagu hawlgeliyaa iyada oo la isku xidho isku xidhka unugyada unugyada ka baxsan (ECM) laakiin waxa laga yaabaa in la hagaajiyo oo si guud ayaa loo hawlgeliyaa noocyada unugyada burooyinka ee kala duwan.

Ujeedka: FAK