Batefeenterol

Magaca Kiimikada:

"(R)-1-(3-(2-chloro-4-((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl))ethyl)amino) methyl-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate Batefenterol Succinate"

Koodhka dhoola cadeynta:

O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

Koodhka InChi:

InChi=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)2 9-11-13-34(47)39-30(29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(1) 6-19-46)53-40(51)44-32-10-6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22, 27, 35,42,47-48H,15-20,23-24H2,1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1

Furaha InChi:

URWYQGVSPQJGGB-DHUJRADRSA-N

Ereyga muhiimka ah:

Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

Sharaxaad:

Batefenterol waa antagonist muscarinic iyo β2-adrenergic reseptor (β2-AR) agonist (Kis = 1.4, 1.3, iyo 3.7 nM, ee hM2, hM3, iyo hβ2-AR, siday u kala horreeyaan baaritaanka radioligand xidhitaanka). Batefenterol wuxuu soo bandhigayaa firfircoonida hβ2-AR agonist xoog leh (EC50 = 0.29 nM) oo leh 440-iyo 320-laab xulashada shaqeynta ee hβ1-iyo hβ3-ARs, siday u kala horreeyaan. nudaha waxayna ka hortagtaa jawaabta bronchoconstrictor ee doofaarka guinea Baaritaanka ilaalinta bronchoprotection (ED50 = 6.4 µg/ml). Daawooyinka ay ku jiraan batefenterol waxay ku jiraan tijaabooyin caafimaad si loo daweeyo cudurka sambabada ee joogtada ah (COPD).

Bartilmaameedka: β2-adrenoceptor