Osimertinib Mesylate

Magaca Kiimikada:

N- (2- (2- (dimethylamino) ethyl) (methyl) amino) -4-methoxy-5-((4- (1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino phenyl) acrylamide mesylate

Koodhka dhoola cadeynta:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4=N2 .OS(=O)(C)=O

Koodhka InChi:

InChi=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19 (20)24;1-5(2,3)4/ h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

Furaha InChi:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Ereyga muhiimka ah:

AZD-9291, AZD9291, AZD 9291, Tagrisso,Osimertinib Mesylate, 1421373-66-1

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo)

Sharaxaad:

Osimertinib, oo sidoo kale loo yaqaan mereletinib iyo AZD-9291, waa jiilka saddexaad ee EGFR inhibitor, wuxuu muujiyay ballan-qaadka daraasadaha saxda ah wuxuuna rajo ka qabaa bukaannada qaba kansarka sambabada sare kuwaas oo u adkeysanaya inhibitors EGFR ee jira. AZD9291 aad ayuu ugu firfircoon yahay moodooyinka hore waxaana si fiican loogu dulqaadanayaa moodooyinka xayawaanka. Waxay joojisaa firfircoonida iyo isu-beddelka EGFR labadaba iyadoo ilaalinaysa qaabka caadiga ah ee EGFR ee ku jira maqaarka caadiga ah iyo unugyada mindhicirka, taas oo hoos u dhigaysa dhibaatooyinka ay la kulmaan daawooyinka hadda la heli karo. Osimertinib ayaa la ansixiyay Noofambar 2015.

Hadafka: EGFR