CP-456773 sodium
Faahfaahinta Alaabta
Tags Product
| Cabbirka Xidhmada | Helitaanka | Qiimaha (USD) |
| 100mg | In Stock | 500 |
| 500mg | In Stock | 800 |
| 1g | In Stock | 1200 |
| Cabiro badan | Hel Xigasho | Hel Xigasho |
Magaca Kiimikada:
sodium ((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)((4- (2-hydroxypropan-2-yl)furan-2-yl)sulfonyl) amide
Koodhka dhoola cadeynta:
O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]
Koodhka InChi:
InChi=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3- 5-12 (15)9-13-6-4-8-16 (13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q; +1/p-1
Furaha InChi:
LFQQNXFKPNZRFT-UHFFFAOYSA-M
Ereyga muhiimka ah:
MCC950, MCC 950, MCC-950, CP-45677, CP45677, CP 45677, CRID-3, CRID3, CRID 3, CP-456773 sodium cusbo, Cytokine sii daayo daawada xakameynaya 3, 256-373-96
Xalka:Ku milmay DMSO
Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).
Sharaxaad:
CP-456773, oo sidoo kale loo yaqaan MCC950 iyo CRID3, waa awood xoog leh oo la xushay cytokine sii-deynta iyo NLRP3 inhibitor inhibitor ah oo loogu talagalay daaweynta cudurrada caabuqa. CP-456773 waxay joojisaa dheecaanka interleukin 1β (IL-1β) iyo ka shaqeynta 1. MCC950 waxay xannibtay hawlgelinta canonical iyo noncanonical NLRP3 ee uruurinta nanomolar. MCC950 ayaa si gaar ah u hakiyay firfircoonida NLRP3 laakiin ma aha caabuqyada AIM2, NLRC4 ama NLRP1. MCC950 waxay hoos u dhigtay wax soo saarka interleukin-1β (IL-1β) ee vivo waxayna hoos u dhigtay darnaanta tijaabinta autoimmune encephalomyelitis (EAE), oo ah nooca cudur ee sclerosis badan. MCC950 waa daaweyn suurtagal ah oo loogu talagalay xanuunka NLRP3-ku xiran, oo ay ku jiraan autoinflammatory iyo cudurrada difaaca jirka, iyo qalab loogu talagalay daraasad dheeraad ah oo ku saabsan caabuqa NLRP3 ee caafimaadka aadanaha iyo cudurrada.
Ujeedka: NLRP3
