FLT3

CAT #	Magaca Alaabta	Sharaxaada
CPDB0099	Quizartinib; AC-010220; AC-220	Quizartinib waa xannibaadaha FMS ee la xidhiidha tyrosine kinase 3 (FLT3; Kd = 1.6 nM) waxayna muujinaysaa xulashada sare ee FLT3 marka lagu tijaabiyo guddi ka mid ah 227 kinase dheeraad ah. Waxay xakameysaa faafinta xariiqda unugyada leukemia ee bini'aadamka MV4-11, kaas oo xajinaya isbeddelka homozygous FLT3-ITD, oo leh IC50 qiimaha 0.56 nM.1 1 mg / kg / maalintii, quizartinib ayaa la muujiyay in ay kordhiso badbaadada jiirka qaabka FLT3-ITD myeloid leukemia ba'an iyo si loo ciribtiro burooyinka FLT3 ku tiirsan mouse xenograft model oo ah 10 mg/kg.