BAY-1895344

Magaca Kiimikada:

(R) -3-methyl-4- (4- (1-methyl-1H-pyrazol-5-yl)-8- (1H-pyrazol-5-yl) -1,7-naphthyridin-2-yl) morpholine

Koodhka dhoola cadeynta:

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

Koodhka InChi:

InChi=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6- 21-2 0(19 (14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25);1H /t13-;/m1./s1

Furaha InChi:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Ereyga muhiimka ah:

1876467-74-1;CAS:1876467-74-1;CAS:1876467-74-1；BAY-1895344,BAY1895344,BAY 1895344

Xalka:Ku milmay DMSO

Kaydinta:0 - 4°C muddo gaaban (maalmo ilaa toddobaadyo), ama -20°C muddo dheer (bilo).

Sharaxaad:

BAY-1895344 waa ATR la xushay (ataxia-telangiectasia iyo borotiinka laxiriira Rad3) xakameynta xakameynta faafitaanka ballaaran ee khadadka unugyada burooyinka bini'aadamka (dhexe IC50 = 78 nM). BAY-1895344 waxaa loo sameeyay daawaynta bukaanada qaba burooyinka adag ee horumaray iyo lymfomas, waxayna maraysaa wajiga I tijaabada caafimaad ee badbaadada iyo dulqaadka bukaanka kansarka.

Ujeedka: ATR