In vitro Baaritaannada Pharmacokinetic

Kooxdayada farmashiyaha waxay ku takhasusaan horumarinta caafimaadka, baaritaanka DMPK iyo diiwaangelinta IND. Waxaan aasaasnay ​​isku-dhafan in vitro & in vivo madal tignoolajiyada baadhista si loo taageero helitaanka iyo horumarinta daroogada. Caerulum Pharma waxay siisaa adeeg dabacsan oo shakhsi ahaaneed oo loogu talagalay xalalka DMPK wax ku ool ah oo kharash-ool ah si kor loogu qaado cilmi-baaristaada.

1.Qaybaha waxbarashada

Unugyada yaryar, alaabta dabiiciga ah, polypeptides.

2.Adeegyada la heli karo

Baaritaanka isku xidhka borotiinka Plasma/unugga

Plasma iyo saamiga dhiigga

Xasiloonida dheef-shiid kiimikaadka microsomal beerka

Degganaanshaha baabuurka iyo balaasmaha

Aqoonsiga dheef-shiid kiimikaadka

CYP falcelinta fenotyping

Joojinta CYP

3.In dhismaha

Beerista Hepatocyte

Caco-2 Permeability

UGT falcelinta fenotyping


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