GSK-461364
Product Detail
Product Tags
| Pack Saizi | Kuwanikwa | Mutengo (USD) |
| 100mg | Mudura | 400 |
| 500mg | Mudura | 1400 |
| Mamwe Saizi | Wana MaQuotes | Wana MaQuotes |
Chemical Name:
(R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy) thiophene-2-carboxamide
SMILES Kodhi:
O=C(C1=C(O[C@@H](C2=CC=CC=C2C(F)(F)F)C)C=C(N3C=NC4=CC=C(CN5CCN(C)CC5 )C=C34)S1)N
InChi Code:
InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31) 36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14, 16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1
InChi Key:
ZHJGWYRLJUCMRT-QGZVFWFLSA-N
Keyword:
GSK-461364, GSK461364, GSK 461364, GSK-461364A, GSK 461364A, GSK461364A, 929095-18-1
Solubility:Soluble muDMSO
Kuchengeta:0 - 4 ° C kwenguva pfupi (mazuva kusvika mavhiki), kana -20 ° C kwenguva refu (mwedzi)
Tsanangudzo:
Polo-like kinases (Plks) ndeye serine / threonine kinases ine mabasa akakosha musero cycling. GSK461364 ine simba, reversible inhibitor yePlk1 (Ki = 2.2 nM). Iyo hainyanyi kushanda paPlk2 nePlk3 (Kis = 860 uye 1,000 nM, zvichiteerana) uye kanenge 1,000-yakapetwa inosarudza Plk1 pamusoro pepaneru ye48 mamwe kinase. GSK461364 dose-inomisa kutenderera kwesero mumitsara yakasiyana-siyana yekenza yekenza uye, pamwero wepamusoro, inokonzera apoptosis. Inoratidzika kunge inoshanda zvakanyanya kupikisa p53-inoshaya mapundu uye inokwanisa kuyambuka ropa-brain barriers. GSK461364 inoshanda mu vivo, ichiita kuti bundu rikure inhibition kana kukura kunonoka mumhando dzexenograft mumakonzo.
Chinangwa: Plk1
