AZD7507

Chemical Name:

4-(2-fluoro-4-methylanilino)-6--[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

SMILES Kodhi:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

InChi Code:

InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31 )20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25, 32)(H,26,27)

InChi Key:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

Keyword:

AZD7507; AZD-7507; AZD 7507

Solubility:DMSO

Kuchengeta: 

Tsanangudzo:

AZD7507 ine simba uye inosarudza CSF-1R inhibitor (32 nM cell chiitiko), AZD7507 inoonekwa sekomisheni inovimbisa sezvo yakachengeta yaidiwa simba uye yemuromo pharmacokinetic zvimiro zveAZ683. Uyezve, mune chidzidzo che telemetry muimbwa dzakapiwa muromo mumwe chete, pakanga pasina chepfu yemwoyo, hapana kukwirira kwetroponin maererano nekurapa, uye hapana kuchinja muECG.

Chinangwa: CSF-1R