TAS-120

Igoa vaila'au:

1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidinyl] -2-propen-1-tasi

SMILES Code:

C=CC(N1C[C@@H](N2N=C(C#CC3=CC(OC)=CC(OC)=C3)C4=C(N)N=CN=C42)CC1)=O

InChi Code:

InChI=1S/C22H22N6O3/c1-4-19(29)27-8-7-15(12-27)28-22-20(21(23)24-13-25-22)18(26-28) 6-5-14-9-16(30-2)11-17(10-14)31-3/h4,9-11,13,15H,1,7-8,12H2,2-3H3,(H2 ,23,24,25)/t15-/m0/s1

InChi Key:

KEIPNCCJPRMIAX-HNNXBMFYSA-N

upu autu:

TAS-120

Solubility: 

Teuina: 

Fa'amatalaga:

O le TAS-120 o se fa'agata fa'aola e mafai ona tu'u gutu o le fibroblast growth factor receptor (FGFR) fa'atasi ai ma gaioiga antineoplastic. FGFR inhibitor TAS-120 filifili ma irreversibly fusifusia ma taofia FGFR, lea e mafai ona iu i le inhibition o le auala uma e lua FGFR-mediated faailo transduction ala ma tumo cell proliferation, ma faateleina le oti cell i FGFR-overexpressing sela tuma. O le FGFR o se fa'ameamea o le tyrosine kinase e mana'omia mo le fa'atuputeleina o sela tumo, fa'avasegaga ma le ola ma o lona fa'aaliga e fa'atulafonoina i le tele o ituaiga sela tumo.

Sini: FGFR