Derazantinib; ARQ-087
Fa'amatalaga Oloa
Faailoga o oloa
| Tele o le afifi | Avanoa | Tau (USD) |
| 10mg | E tele | 800 |
| 100mg | E tele | 1200 |
| 500mg | E tele | 1800 |
| Tele Tele | Maua Upusii | Maua Upusii |
Igoa vaila'au:
(6R)-6-(2-fluorophenyl)-5,6-dihydro-N-[3-[2-[(2-methoxyethyl)amino]ethyl]phenyl]-Benzo[h]quinazolin-2-amine
SMILES Code:
COCCNCCC1=CC(NC2=NC=C3C[C@@H](C4=CC=CC=C4F)C5=CC=CC=C5C3=N2)=CC=C1
InChi Code:
InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24- 10-4-5-12-2 7(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H ,32,33,34)/t26-/m1/s1
InChi Key:
KPJDVVCDVBFRMU-AREMUKBSSA-N
upu autu:
Derazantinib, ARQ-087, ARQ087, ARQ 087, 1234356-69-4
Solubility:Solu i le DMSO
Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), poo le -20°C mo taimi uumi (masina).
Fa'amatalaga:
Derazantinib, e lauiloa foi o le ARQ-087, o se iniseti e mafai ona tuʻu tautala o le fibroblast growth factor receptor (FGFR) faʻatasi ai ma gaioiga antineoplastic. FGFR inhibitor ARQ 087 fusifusia ma malosi faʻalavelaveina le gaioiga o FGFR subtypes 1, 2 ma 3. E mafai ona iʻu ai i le faʻalavelaveina o ala faʻaliliuina faʻailoga FGFR-mediated, faʻateleina o le tumo cell, tumo angiogenesis ma le mate o le tumo cell i FGFR-overexpressing sela tumo. . FGFR, o le receptor tyrosine kinase, e faʻatulafonoina i le tele o ituaiga sela tumo ma e iai sona sao taua i le faʻateleina o le tumo, faʻavasegaina, angiogenesis ma le ola.
Sini: FGFR
