TH-302; Evofosfamide

Igoa vaila'au:

N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester

SMILES Code:

O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C

InChi Code:

InChI=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

InChi Key:

UGJWRPJDTDGERK-UHFFFAOYSA-N

upu autu:

TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

O le Evofosfamide, lea e lauiloa foi o le TH-302, o se vailaʻau faʻaogaina o le hypoxia e aofia ai le 2-nitroimidazole phosphoramidate conjugate ma le gaioiga antineoplastic. Ole vaega ole 2-nitroimidazole ole hypoxia-activated prodrug TH-302 o loʻo galue o se faʻaosoina o le hypoxic, faʻasaʻolotoina le DNA-alkylating dibromo isophosphoramide sinapi vaega i totonu o itulagi hypoxic o tuma. E mafai ona fa'asaoina le tino o Normoxic ona o le gaioiga fa'apitoa o le hypoxia a lenei vaila'au, e ono fa'aitiitia ai le o'ona. Siaki mo faʻataʻitaʻiga faʻapitoa faʻataʻitaʻiga poʻo faʻataʻitaʻiga tapuni faʻataʻitaʻiga e faʻaaoga ai lenei sooupu. (NCI).

Sini: DNA Alkylating Agent