EAI-045

Igoa vaila'au:

2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide

SMILES Code:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

InChi Code:

InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8 -27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)

InChi Key:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

upu autu:

EAI-045, EAI045, EAI 045, 1942114-09-1

Solubility:Solu i le DMSO

Teuina:0 - 4°C mo taimi pupuu (aso i vaiaso), po'o le -20°C mo taimi uumi (masina)

Fa'amatalaga:

EAI045 o se malosi ma filifilia EGFR inhbitor. O le EAI045 o loʻo faʻamoemoeina e suitulaga EGFR e tetee i vailaʻau ae faʻasaoina le faʻaogaina o le vao. EAI045 faʻalavelave L858R / T790M-mutant EGFR faʻatasi ai ma le malosi maualalo-nanomolar i suʻesuʻega biochemical.

Sini: EGFR