Voruciclib

Izina ryimiti:

2- (2-Chloro-4-. -4-umwe

Kode ya SMILES:

O = C1C = C (C2 = CC = C (C (F) (F) F) C = C2Cl) OC3 = C ([C @ H] 4 [C @ H] (CO) N (C) CC4) C (O) = CC (O) = C13

InChi Code:

InChI = 1S / C22H19ClF3NO5 / c1-27-5-4-12 (14 (27) 9-28) 19-15 (29) 7-16 (30) 20-17 (31) 8-18 (32-21 ( 19) 20) 11-3-2-10 (6-13 (11) 23) 22 (24,25) 26 / h2-3,6-8,12,14,28-30H, 4-5,9H2, 1H3 / t12-, 14 + / m1 / s1

InChi Urufunguzo:

MRPGRAKIAJJGMM-OCCSQVGLSA-N

Ijambo ryibanze:

P1446A05, P1446A-05, P1446A 05, Voruciclib

Gukemura: 

Ububiko: 

Ibisobanuro:

Voruciclib, izwi kandi nka P1446A-05, ni poroteyine ya kinase inhibitor yihariye ya kinase iterwa na kinase 4 (CDK4) ifite ibikorwa bya antineoplastique. CDK4 inhibitor P1446A-05 irabuza cyane cyane CDK4 yunganirwa na G1-S icyiciro cya kabiri, gufata amagare ya selile no kubuza gukura kwa kanseri. Serine / threonine kinase CDK4 iboneka murwego rufite D-G1 yo mu bwoko bwa G1 kandi niyo kinase ya mbere yatangiye gukora nyuma yo gukanguka kwa mitogenic, ikarekura ingirabuzimafatizo kuva mukanya gato ikagera kuri G1 / S. CDK-cyclin yerekanwe kuri fosifora yibintu byandikirwa retinoblastoma (Rb) mugitangiriro cya G1, ikuraho histone deacetylase (HDAC) no guhagarika gukandamizwa.

Intego: CDK4