LDC000067

Izina ryimiti:

3 - [[6- (2-Methoxyphenyl) -4-pyrimidinyl] amino] benzenemethanesulfonamide

Kode ya SMILES:

O = S (CC1 = CC = CC (NC2 = NC = NC (C3 = CC = CC = C3OC) = C2) = C1) (N) = O

InChi Code:

InChI = 1S / C18H18N4O3S / c1-25-17-8-3-2-7-15 (17) 16-10-18 (21-12-20-16) 22-14-6-4-5-13 ( 9-14) 11-26 (19,23) 24 / h2-10,12H, 11H2,1H3, (H2,19,23,24) (H, 20,21,22)

InChi Urufunguzo:

GGQCIOOSELPMBB-UHFFFAOYSA-N

Ijambo ryibanze:

LDC000067; LDC-000067; LDC 000067

Gukemura: 

Ububiko: 

Ibisobanuro:

LDC000067 ninzitizi ikomeye kandi itoranya CDK9. LDC000067 yabujijwe kwandukura vitro muburyo bwa ATP-irushanwa kandi ikabije. Imvugo yerekana imiterere ya selile zavuwe na LDC000067 yerekanaga igabanuka ryatoranijwe rya mRNAs zimara igihe gito, harimo nubugenzuzi bukomeye bwo gukwirakwiza na apoptose. Isesengura rya de novo RNA synthesis ryagaragaje uruhare runini rwa CDK9. Ku rwego rwa molekuline na selile, LDC000067 yerekanye ingaruka ziranga CDK9 nko guhagarika ihagarikwa rya RNA polymerase II kuri gen, cyane cyane, kwinjiza apoptose mungirangingo za kanseri. LDC000067 ibuza P-TEFb iterwa na transcription. Itera apoptose muri vitro no muri vivo ifatanije na BI 894999.

Intego: CDK9